Progress on role of CCN1 in pulmonary diseases / 中国病理生理杂志

Cysteine-rich angiogenic inducer 61(Cyr61/CCN1)is an extracellular matrix-associated signaling protein consisting of 381 amino-acid residues ,which has the regulatory function for a multitude of cellular responses.The pleiotropic effects of CCN 1 on the initiation and resolution of inflammation as well as oncogenesis and development of tumor were reported.According to the numerous data from experimental and clinical studies ,this article provides an overview on CCN1 and summarizes the latest understanding of the role of CCN 1 in pulmonary diseases.